Professor of Pharmacology and Cancer Biology
Professor in Psychiatry and Behavioral Sciences
Professor in Neurobiology
Duke University School of Medicine
Durham, NC 27710
Research in this laboratory is aimed toward understanding the cellular and molecular mechanisms that control neuronal development in the fetus, newborn and adolescent, especially the adverse effects of drugs of abuse and environmental contaminants. Ongoing projects comprise three areas:
(1) Mechanisms regulating development of synapses: ontogeny of neurotransmitter receptors and intracellular signaling cascades; endocrine and trophic factors.
(2) Adverse effects of exogenous agents on development: drugs of abuse (especially nicotine), hormonal imbalances, environmental contaminants (pesticides), drug therapies for preterm labor.
(3) Unique biological properties of the adolescent brain: their role in addiction and neural injury by environmental toxicants.
Powers, C.M., A.R. Badireddy, I.T. Ryde, F.J. Seidler and T.A. Slotkin, 2011. Silver nanoparticles compromise neurodevelopment in PC12 cells: critical contributions of silver ion, particle size, coating and composition. Environmental Health Perspectives 119: 37-44.
Powers, C.M., E.D. Levin, F.J. Seidler and T.A. Slotkin, 2011. Silver exposure in developing zebrafish produces persistent synaptic and behavioral changes. Neurotoxicology and Teratology 33: 329-332.
Slotkin, T.A., 2011. Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity? Reproductive Toxicology 31: 297-301.
Slotkin, T.A., Seidler, F.J., 2012. Developmental neurotoxicity of organophosphates targets cell cycle and apoptosis, revealed by transcriptional profiles in vivo and in vitro. Neurotoxicol. Teratol. 34, 232-241.
Slotkin, T.A., Seidler, F.J., Spindel, E.R., 2011. Prenatal nicotine exposure in rhesus monkeys compromises development of brainstem and cardiac monoamine pathways involved in perinatal adaptation and Sudden Infant Death Syndrome: amelioration by Vitamin C. Neurotoxicol. Teratol. 33, 431-434.